Van de Ven Double Halts The Toffees' Run at Brand New Stadium
The Dutch defender became the first defender to score two goals in a Premier League match for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven heads into the net two times in opening period
Everton's Jake O'Brien has equalizer ruled after VAR review
Senegalese midfielder scores third in 89th minute
This loss is Everton's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs extended their winning streak in away games in the top division and delivered Everton their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven pounced twice from set-pieces in the first half to put their strong form at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker Richarlison - nodded in a third to seal the victory.
Jake O'Brien believed he had equalized the scores five minutes after Van de Ven's first goal, glancing a bullet header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, missed a handful of opportunities, while Vicario made a succession of fine stops to guarantee Tottenham went five away games without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to check the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
This victory moves Thomas Frank's team into third place in the Premier League, five points off local foes and table-toppers Arsenal.
Everton remain 14th and sit half a dozen points clear of the drop zone.
Spurs breakdown: The defender fulfils duties at both ends of the field
After a uninspiring midweek display in the Champions League against the French side, where they mustered a only two shots on target, Frank chose the French striker in attack instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for the substitute after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven converted into an offensive threat to be feared.
Spurs' opening strike came from a well-worked corner routine, with the midfielder heading the ball toward the six-yard box for an unmarked the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's absence - notched his second in added time as he rose above the England keeper to head home.
The Dutchman was just as impressive in defence, partnering effectively with his defensive colleague as the pair dealt superbly with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the freshness may have faded slightly and supporters flocked to the gates after Sarr's third for Spurs.
The end in Everton's winning streak at home will not be a massive concern for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Everton's pair of established centre-forwards - had netted only one league goal combined before the weekend's match.
And they were unable to contribute to that miserable record on a wet and gloomy evening on in Liverpool.
Beto's performance was epitomized when he opted to overhead kick a clear chance from near the goal, despite having room and time to readjust for a more conventional shot that would have challenged Vicario.
The substitute, as well, failed to influence the game after coming on for the starter in the second half.
It was not for a shortage of opportunity. The majority of Everton's attacks came through Grealish and the forward, who relentlessly whipped threatening crosses into the Tottenham penalty area.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men travel to Sunderland in the top flight on early November at 8 PM.
Tottenham: The London club travel to St James' Park on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.